Journal article
HIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies
PR Gorry, N Francella, SR Lewin, RG Collman
Journal of Leukocyte Biology | WILEY | Published : 2014
DOI: 10.1189/jlb.0713368
Abstract
Myeloid cells residing in the CNS and lymphoid tissues are targets for productive HIV-1 replication, and their infection contributes to the pathological manifestations of HIV-1 infection. The Envs can adopt altered configurations to overcome entry restrictions in macrophages via a more efficient and/or altered mechanism of engagement with cellular receptors. This review highlights evidence supporting an important role for macrophages in HIV-1 pathogenesis and persistence, which need to be considered for strategies aimed at achieving a functional or sterilizing cure. We also highlight that the molecular mechanisms underlying HIV-1 tropism for macrophages are complex, involving enhanced and/or..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
P.R.G. is the recipient of an Australian Research Council Future Fellowship (FT2) and is supported by grants from the Australian National Health and Medical Research Council (#1006534 and #1022066) and funds from the Victorian Operational Infrastructure Support Program received by the Burnet Institute. R.G.C. was supported by U.S. National Institutes of Health grants MH061139 and AI091516 and received assistance from the Penn Center for AIDS Research (CFAR; AI045008). N.F. was supported by U.S. National Institutes of Health Grant T32-AI007632. We thank Jasminka Sterjovski for assistance with preparing the figure.